Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation
Author:
Affiliation:
1. Department of Chemistry
2. Umeå University
3. SE-901 87 Umeå
4. Sweden
5. Department of Chemistry and Biochemistry
Abstract
Despite the importance of kinases' catalytic activity regulation in cell signaling, detailed mechanisms underlying their activity regulation are poorly understood.
Funder
Vetenskapsrådet
Umeå University
University of Texas at Arlington
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00055C
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