Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones-Reference-Cited by-同舟云学术

Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

Published:2018 Issue:1 Volume:16 Page:53-56
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Alanine Thomas A.¹²³⁴⁵^ORCID,Stokes Stephen¹²³⁴⁵,Roberts Craig A.¹²³⁶⁵,Scott James. S.¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal Chemistry

2. Oncology

3. IMED Biotech Unit

4. Cambridge CB4 0FZ

5. United Kingdom

6. Macclesfield SK10 4TG

Abstract

Pd-Catalysed C–H aziridination of 3,3,5,5-tetrasubsituted piperazin-2-ones catalysed by succinic acid. The mechanistic role of the acid is investigated through kinetics experiments.

Funder

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02486J

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