The ENGases: versatile biocatalysts for the production of homogeneous N-linked glycopeptides and glycoproteins

Author:

Fairbanks Antony J.12345ORCID

Affiliation:

1. Department of Chemistry

2. University of Canterbury

3. Christchurch 8140

4. New Zealand

5. Biomolecular Interaction Centre

Abstract

Synthetic applications of ENGase enzymes allow the production of a wide variety of homogenous glycopeptides and glycoproteins, including therapeutic mAbs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference140 articles.

1. A. Varki , R. D.Cummings, J. D.Esko, H. H.Freeze, P.Stanley, C. R.Bertozzi, G. W.Hart and M. E.Etzler, Essentials of Glycobiology, Cold Spring Harbour Laboratory Press, Cold Spring Harbour, NY, 2009

2. Intracellular Functions of N-Linked Glycans

3. Therapeutic monoclonal antibodies and derivatives: Historical perspectives and future directions

4. Glycosylation of Recombinant Antibody Therapeutics

5. Glycosylation as a strategy to improve antibody-based therapeutics

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