Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines-Reference-Cited by-同舟云学术

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines

Published:2016 Issue:2 Volume:14 Page:455-459
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Richards Daniel A.¹²³⁴,Fletcher Sally A.¹²³⁴,Nobles Muriel⁵⁶³⁴,Kossen Hanno¹²³⁴,Tedaldi Lauren¹²³⁴,Chudasama Vijay¹²³⁴,Tinker Andrew⁵⁶³⁴,Baker James R.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University College London

3. London

4. UK

5. Barts and The London

6. Queen Mary's School of Medicine and Dentistry

Abstract

Descibed is a method to photochemically re-bridge disulfide bonds by carrying out [2 + 2] photocycloadditions on tagged cysteine residues. A photodecarboxylation of C-terminal cysteines is also discovered.

Funder

Novartis Pharmaceuticals Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02120K

Reference30 articles.

1. Light-Induced Click Reactions

2. Bioorthogonal chemistry: strategies and recent developments

3. Photochemical tools to study dynamic biological processes