Tissue-mimetic hybrid bioadhesives for intervertebral disc repair

Author:

Li Xuan1ORCID,Liu Yin2,Li Li3,Huo Ran1ORCID,Ghezelbash Farshid14,Ma Zhenwei1ORCID,Bao Guangyu1ORCID,Liu Shiyu1ORCID,Yang Zhen1ORCID,Weber Michael H.3,Li-Jessen Nicole Y. K.256ORCID,Haglund Lisbet3,Li Jianyu123ORCID

Affiliation:

1. Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, QC H3A 0C3, Canada

2. Department of Biomedical Engineering, McGill University, 3775 rue University, Montreal, Quebec H3A 2B4, Canada

3. Department of Surgery, McGill University, 1650 Cedar Avenue, Room C10.148.2, Montreal, QC, H3G 1A4, Canada

4. Department of Mechanical Engineering, Polytechnique Montreal, Montreal, Quebec H3C 3A7, Canada

5. School of Communication Sciences and Disorders, McGill University, Montreal, Quebec H3A 1G1, Canada

6. Department of Otolaryngology-Head & Neck Surgery, McGill University, Montreal, Quebec H3A 1G1, Canada

Abstract

Tissue-mimetic hybrid bioadhesives for the repair of intervertebral disc after nucleotomy is proposed, comprising a viscoelastic glue for delivering cells to fill the cavity and a tough adhesive sealant to prevent re-herniation post-nucleotomy.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

Reference77 articles.

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