Stereochemistry of the peptide α-amidation reaction involving two enzymes, peptidylglycine α-hydroxylating monooxygenase (PHM) and peptidylhydroxyglycine N

Stereochemistry of the peptide α-amidation reaction involving two enzymes, peptidylglycine α-hydroxylating monooxygenase (PHM) and peptidylhydroxyglycine N–C lyase (PHL)

Published:1992 Issue:8 Volume:0 Page:625-626
ISSN:0022-4936
Container-title:J. Chem. Soc., Chem. Commun.
language:en
Short-container-title:J. Chem. Soc., Chem. Commun.

Author:

Kawahara Takashi,Suzuki Kenji,Iwasaki Yasuno,Shimoi Hiroko,Akita Munetaka,Moro-Oka Yoshihiko,Nishikawa Yoshiki

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/1992/C3/C39920000625

Reference11 articles.

1. Peptide amidation

2. Peptide α-Amidation

3. Elucidation of amidating reaction mechanism by frog amidating enzyme, peptidylglycine alpha-hydroxylating monooxygenase, expressed in insect cell culture.

4. A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of .alpha.-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine .alpha.-amidating monooxygenase in peptide amidation

5. Peptidylglycine α-amidating reaction: Evidence for a two-step mechanism involving a stable intermediate at neutral pH

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