Antiproliferative activity and toxicity evaluation of 1,2,3-triazole and 4-methyl coumarin hybrids in the MCF7 breast cancer cell line-Reference-Cited by-同舟云学术

Antiproliferative activity and toxicity evaluation of 1,2,3-triazole and 4-methyl coumarin hybrids in the MCF7 breast cancer cell line

Published:2023 Issue:5 Volume:14 Page:869-879
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Augsten Lucas Volnei¹^ORCID,Göethel Gabriela¹²,Gauer Bruna¹,Feiffer Charão Mariele²,von Poser Gilsane³,Canto Romulo F. S.⁴,Arbo Marcelo Dutra²,Eifler-Lima Vera Lucia¹^ORCID,Garcia Solange Cristina²

Affiliation:

1. Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752 Laboratório 705, Porto Alegre, RS, Brazil

2. Laboratório de Toxicologia (LATOX), Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

3. Laboratório de Farmacognosia, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga 2752 – Santa Cecília, CEP 90610-000, Porto Alegre, RS, Brazil

4. Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre, RS, Brazil

Abstract

Coumarin–triazole hybrids went through antitumor activity screening, finding anti-breast cancer cell line MCF7 activity, besides antioxidant activity, mitochondrial membrane disruption and no DNA damage.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00031A

Reference39 articles.

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2. Coumarins as Potential Antioxidant Agents Complemented with Suggested Mechanisms and Approved by Molecular Modeling Studies

3. Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities

4. Natural and Synthetic Coumarins with Effects on Inflammation

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