A combination of docking and cheminformatics approaches for the identification of inhibitors against 4′ phosphopantetheinyl transferase ofMycobacterium tuberculosis-Reference-Cited by-同舟云学术

A combination of docking and cheminformatics approaches for the identification of inhibitors against 4′ phosphopantetheinyl transferase ofMycobacterium tuberculosis

Published:2018 Issue:1 Volume:8 Page:328-341
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Rohilla Akshay¹²³^ORCID,Khare Garima¹²³^ORCID,Tyagi Anil K.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry

2. University of Delhi South Campus

3. India

4. Guru Gobind Singh Indraprastha University

5. Dwarka

Abstract

We integrated virtual screening,in vitroandex vivoapproaches to identify numerous potent inhibitory scaffolds againstM. tbPptT.

Funder

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA11198C

Reference21 articles.

1. WHO tuberculosis report, 2016, http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf?ua=1

2. Tuberculosis Drug Resistance: A Global Threat

3. XDR Tuberculosis — Implications for Global Public Health

4. Post-translational modification of polyketide and nonribosomal peptide synthases

5. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis

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