A combination of docking and cheminformatics approaches for the identification of inhibitors against 4′ phosphopantetheinyl transferase ofMycobacterium tuberculosis
Author:
Affiliation:
1. Department of Biochemistry
2. University of Delhi South Campus
3. India
4. Guru Gobind Singh Indraprastha University
5. Dwarka
Abstract
We integrated virtual screening,in vitroandex vivoapproaches to identify numerous potent inhibitory scaffolds againstM. tbPptT.
Funder
Department of Biotechnology, Ministry of Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA11198C
Reference21 articles.
1. WHO tuberculosis report, 2016, http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf?ua=1
2. Tuberculosis Drug Resistance: A Global Threat
3. XDR Tuberculosis — Implications for Global Public Health
4. Post-translational modification of polyketide and nonribosomal peptide synthases
5. Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis
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2. In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas;Journal of Medicinal Chemistry;2022-01-19
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