Exploring molecular reorientations in amorphous and recrystallized felodipine at the microscopic level
Author:
Affiliation:
1. Faculty of Physics
2. Adam Mickiewicz University
3. 61-614 Poznań
4. Poland
5. NanoBioMedical Centre
6. Laboratory for Neutron Scattering and Imaging
7. Paul Scherrer Institut
8. Switzerland
Abstract
Molecular reorientations were studied in amorphous, partially and fully recrystallized felodipine using a set of experimental methods: high-resolution solid-state nuclear magnetic resonance (NMR), relaxometry NMR and quasielastic neutron scattering (QENS).
Funder
Joint Institute for Nuclear Research
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA07266D
Reference53 articles.
1. Structural and Dynamic Properties of Amorphous Solid Dispersions: The Role of Solid-State Nuclear Magnetic Resonance Spectroscopy and Relaxometry
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3. Molecular Dynamics and Physical Stability of Amorphous Anti-Inflammatory Drug: Celecoxib
4. Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility
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1. Role of Crystal Disorder and Mechanoactivation in Solid-State Stability of Pharmaceuticals;Journal of Pharmaceutical Sciences;2023-06
2. Low-Frequency Raman Spectroscopy as an Avenue to Determine the Transition Temperature of β- and γ-Relaxation in Pharmaceutical Glasses;Analytical Chemistry;2022-06-01
3. The Physical Stability of Felodipine and Its Recrystallization from an Amorphous Solid Dispersion Studied by NMR Relaxometry;AAPS PharmSciTech;2022-03-21
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