Direct β-selectivity of α,β-unsaturated γ-butyrolactam for asymmetric conjugate additions in an organocatalytic manner-Reference-Cited by-同舟云学术

Direct β-selectivity of α,β-unsaturated γ-butyrolactam for asymmetric conjugate additions in an organocatalytic manner

Published:2018 Issue:51 Volume:8 Page:28874-28878
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhong Yuan¹²³⁴⁵,Hong Sihua¹²³⁴,Cai Zhengjun¹²³⁴,Ma Shixiong⁵⁶⁷⁸⁴,Jiang Xianxing¹²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Sun Yat-Sen University

3. Guangzhou

4. China

5. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

6. School of Basic Medical Sciences

7. Lanzhou University

8. Lanzhou

Abstract

The asymmetric addition of γ-butyrolactam with cyclic imino esters catalyzed by (DHQD)₂AQN has been developed, which provides an access to β-position functionalized pyrrolidin-2-one derivatives in high levels yield and enantioselectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA05264F

Reference56 articles.

1. Enantioselective Organocatalysis

2. In the Golden Age of Organocatalysis

3. The advent and development of organocatalysis

4. Asymmetric Organocatalysis: From Infancy to Adolescence

5. Organocatalytic cascade reactions as a new tool in total synthesis

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