Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging

Author:

Nguyen Tuyen Duong Thanh12345,Pitchaimani Arunkumar12345,Ferrel Colin52346,Thakkar Ravindra52346,Aryal Santosh12345ORCID

Affiliation:

1. Department of Chemistry

2. Kansas State University

3. Manhattan

4. USA

5. Nanotechnology Innovation Center of Kansas State (NICKS)

6. Department of Anatomy and Physiology

Abstract

We uniquely engineered targeted hybrid nanoconstruct (HNC) made up of PLGA and superficially decorated with bone targeting agent, alendronic acid, whose inner polymeric core is confined with 5 nm SPIONs by tuning the distance between the clustering SPIONs. Effect of such cluster confinement in the magnetic properties of HNC was studied in detail.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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