Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue-Reference-Cited by-同舟云学术

Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue

Published:2023 Issue:12 Volume:4 Page:1050-1063
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Hennrich Oliver¹,Weinmann Leoni²,Kulik Andreas³^ORCID,Harms Karen⁴^ORCID,Klahn Philipp⁵⁶^ORCID,Youn Jung-Won²,Surup Frank⁴^ORCID,Mast Yvonne¹⁷⁸^ORCID

Affiliation:

1. Department Bioresources for Bioeconomy and Health Research, Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany

2. Institute of Microbiology, University Stuttgart, Allmandring 31, D-70569 Stuttgart, Germany

3. Department Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, Faculty of Science, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany

4. Microbial Drugs Department, Helmholtz-Centre for Infection Research, 38124 Braunschweig, Germany

5. Division of Organic and Medicinal Chemistry, Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 4, 412 96 Göteborg, Sweden

6. Centre of Antimicrobial Resistance Research in Gothenburg (CARe), Gothenburg, Sweden

7. Technische Universität Braunschweig, Institut für Mikrobiologie, Rebenring 56, 38106 Braunschweig, Germany

8. German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany

Abstract

Here, we report the development of a mutasynthesis approach for the derivatisation of pristinamycin I based on the phenylglycine residue in combination with a biotransformation process for mutasynthon provision.

Funder

Leibniz-Gemeinschaft

Deutsches Zentrum für Infektionsforschung

Baden-Württemberg Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D3CB00143A

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