Hydrogen bond synthon competition in the stabilization of theophylline cocrystals

Author:

Sarma Bipul123,Saikia Basanta123

Affiliation:

1. Department of Chemical Sciences

2. Tezpur University

3. Tezpur-784028, India

Abstract

In the preparation of theophylline cocrystals, phenol coformers facilitate water assimilation due to their weaker O–H⋯N(imidazole) synthon. The presence of –COOH prevents water incorporation and provides added physical stability at high humidity. This study shows the feasibility of cocrystal design of an API to tune physical properties based on hydrogen bond synthons.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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