A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging-Reference-Cited by-同舟云学术

A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging

Published:2015 Issue:2 Volume:140 Page:574-581
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Xu Jian¹²³⁴⁵,Sun Shaobo⁶⁷⁴⁵,Li Qian¹²³⁴⁵,Yue Ying¹²³⁴⁵,Li Yingdong⁶⁷⁴⁵,Shao Shijun¹²³⁴⁵

Affiliation:

1. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province

2. Lanzhou Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Lanzhou 730000

5. P. R. China

6. Institute of Integrated Traditional and Western Medicine

7. Gansu University of Chinese Medicine

Abstract

A novel “Turn-On” fluorescent probe, quaternarized 4-pyridinyl-substituted BODIPY dye by incorporating a 5-nitrofuran moiety, was developed and applied for imaging the hypoxic status of tumor cells by the indirect detection of nitroreductase.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/AN/C4AN01934B

Reference52 articles.

1. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation

2. Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia

3. Hypoxia Regulates Macrophage Functions in Inflammation

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