Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)

Published:2019 Issue:50 Volume:9 Page:29023-29036
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mhetre Amol B.¹²³⁴,Sreedhar Eppakayala¹²³⁴,Dubey Rashmi¹²³⁴,Sable Ganesh A.¹²³⁴,Lee Hangeun¹²³⁴,Yang Heekyoung⁵⁶⁷⁸⁴,Lee Kyoungmin⁵⁶⁷⁸⁴,Nam Do-Hyun⁵⁶⁷⁸⁴,Lim Dongyeol¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Sejong University

3. Seoul 143-747

4. Republic of Korea

5. Department of Neurosurgery

6. Samsung Medical Center

7. Sungkyunkwan University School of Medicine

8. Seoul

Abstract

Incorporation of a methoxy substituent at the C-7 position of CBI and N-amido substitution at the C-5 position of benzoselenophene significantly enhances the anticancer activity of duocarmycin analogs.

Funder

Korea Health Industry Development Institute

National Research Foundation of Korea

Ministry of Science ICT and Future Planning

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA04749B

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