Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats

Author:

Yang Yang1ORCID,Qu Yuan1,Lv Xiaoqiang1,Zhao Ruijin1,Yu Jing1,Hu Suying1,Kang Jingqi1,Zhang Yaling1,Gong Ye1,Cui Tingting1,Zhang Xin1,Yan Yaping1ORCID

Affiliation:

1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China

Abstract

Sesamol alleviated NASH and atherosclerosis and regulated the generation of uric acid and activation of uric acid-linked signal pathways in HF-HCC diet-fed rats; it may, therefore, be a potent dietary supplement for protection against these diseases.

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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