Synthesis and immunological effects of C14-linked 4,5-epoxymorphinan analogues as novel heroin vaccine haptens-Reference-Cited by-同舟云学术

Synthesis and immunological effects of C14-linked 4,5-epoxymorphinan analogues as novel heroin vaccine haptens

Published:2021 Issue:3 Volume:2 Page:835-842
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Gutman Eugene S.¹²³⁴⁵,Irvin Thomas C.¹²³⁴⁵,Morgan J. Brian¹²³⁴⁵,Barrientos Rodell C.⁶⁷⁸⁹¹⁰^ORCID,Torres Oscar B.⁶⁷⁸⁹¹⁰,Beck Zoltan⁶⁷⁸⁹¹⁰,Matyas Gary R.⁶⁷⁸⁹¹⁰,Jacobson Arthur E.¹²³⁴⁵,Rice Kenner C.¹²³⁴⁵

Affiliation:

1. Drug Design and Synthesis Section

2. Molecular Targets and Medications Discovery Branch

3. Intramural Research Program

4. National Institute on Drug Abuse and The National Institute on Alcohol Abuse and Alcoholism

5. National Institutes of Health

6. Laboratory of Adjuvant and Antigen Research

7. U.S. Military HIV Research Program

8. Walter Reed Army Institute of Research

9. Silver Spring

10. USA

Abstract

Three novel opiate surrogates with the linker at C14, 1 (6,14-AmidoHap), 2 (14-AmidoMorHap), and 3 (14-AmidoHerHap) were conjugated to tetanus toxoid (TT) and tested as heroin vaccines. The C3 and C6 moieties are crucial in antibody selectivity.

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Henry M. Jackson Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00029B

Reference38 articles.

1. The Opioid Epidemic: Crisis and Solutions