Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation-Reference-Cited by-同舟云学术

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Published:2016 Issue:48 Volume:14 Page:11426-11437
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ohyoshi Takayuki¹²³⁴⁵,Tamura Yuki⁶⁷⁵,Hayakawa Ichiro⁸⁹¹⁰¹¹⁵,Hirai Go⁶⁷⁵¹²⁷,Miyazawa Yamato¹²³⁴⁵,Funakubo Shota¹²³⁴⁵,Sodeoka Mikiko⁶⁷⁵¹²⁷,Kigoshi Hideo¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Graduate School of Pure and Applied Sciences

3. University of Tsukuba

4. Tsukuba 305-8571

5. Japan

6. Synthetic Organic Chemistry Laboratory

7. Wako

8. Division of Applied Chemistry

9. Graduate School of Natural Science and Technology

10. Okayama University

11. Okayama 700-8530

12. RIKEN Center for Sustainable Resource Science

Abstract

Natural derivatives and artificial analogs of 13-oxyingenol were synthesized, and these analogs induced HL-60 differentiation and apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB02268E

Reference63 articles.

1. New diterpene, 13-oxyingenol, derivative isolated from liou.

2. Structure determination of the new tetracyclic diterpene ingenol-triacetate with triple product methods

3. Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

4. Ingenol Derivatives are Highly Potent and Selective Inhibitors of HIV Replication in Vitro

5. Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives

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