Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell lines via ROS-induced apoptosis-Reference-Cited by-同舟云学术

Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell lines via ROS-induced apoptosis

Published:2020 Issue:23 Volume:49 Page:7842-7851
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Icsel Ceyda¹²³⁴⁵,Yilmaz Veysel T.¹²³⁴⁵^ORCID,Aydinlik Seyma⁶⁷⁸⁵,Aygun Muhittin⁹¹⁰¹¹¹²⁵

Affiliation:

1. Department of Chemistry

2. Faculty of Arts and Sciences

3. Bursa Uludag University

4. 16059 Bursa

5. Turkey

6. TUBITAK Marmara Research Center

7. Genetic Engineering and Biotechnology Institute

8. 41470 Gebze

9. Department of Physics

10. Faculty of Sciences

11. Dokuz Eylul University

12. 35210 Izmir

Abstract

Highly cytotoxic Zn(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine cause G0/G1 cell cycle arrest, excessive ROS generation, and mitochondrial and DNA damage in A549 and MCF-7 cell lines, respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01535K

Reference51 articles.

1. Metal complexes of saccharin

2. Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste

3. Carbonic anhydrase inhibitors

4. Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes

5. Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

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