Constrained evolution of a bispecific enzyme: lessons for biocatalyst design
Author:
Affiliation:
1. Research School of Chemistry
2. Australian National University
3. Canberra
4. Australia
5. Commonwealth Scientific and Industrial Research Organisation
Abstract
Analysis of the natural evolution of bispecificity in triazine hydrolase highlights the importance of epistasis in protein engineering and evolution.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02355J
Reference63 articles.
1. Reverse evolution leads to genotypic incompatibility despite functional and active site convergence
2. Stability-mediated epistasis constrains the evolution of an influenza protein
3. Contingency and entrenchment in protein evolution under purifying selection
4. Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape
5. Historical contingency and its biophysical basis in glucocorticoid receptor evolution
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