Attenuation of thrombin-mediated fibrin formationviachanges in fibrinogen conformation induced by reaction withS-nitroso-N-acetylpenicillamine, but notS-nitrosoglutathione
Author:
Affiliation:
1. Department of Surgery, University of Michigan Medical Center
2. Ann Arbor
3. USA
4. Department of Materials Science and Engineering, University of Central Florida
5. Department of Chemistry, University of Michigan
Abstract
A working hypothesis is thatS-nitrosothiols (RSNOs) negatively affect the formation of fibrin through structural changes in fibrinogen and not by inhibiting thrombin activity.
Funder
National Heart, Lung, and Blood Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2018/TB/C8TB02103A
Reference115 articles.
1. Fibrinogen and fibrin structure and functions
2. Fibrinogen Structure and Fibrin Clot Assembly
3. The Structure and Biological Features of Fibrinogen and Fibrin
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