Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers-Reference-Cited by-同舟云学术

Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers

Published:2015 Issue:11 Volume:13 Page:3416-3431
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kamal Ahmed¹²³⁴,Reddy Vangala Santhosh¹²³⁴,Shaik Anver Basha¹²³⁴,Kumar G. Bharath¹²³⁴,Vishnuvardhan M. V. P. S.¹²³⁴,Polepalli Sowjanya⁵³⁴,Jain Nishant⁵³⁴

Affiliation:

1. Medicinal Chemistry and Pharmacology

2. CSIR – Indian Institute of Chemical Technology

3. Hyderabad-500 007

4. India

5. Centre for Chemical Biology CSIR – Indian Institute of Chemical Technology

Abstract

A new class of pyrazole conjugates were synthesized and evaluated for their antiproliferative activity in human cancer cell lines: 9a, 9b and 9f significantly inhibited cell growth as well as tubulin polymerization.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02449D

Reference50 articles.

1. Tubulin and microtubule structure

2. Antitubulin agents for the treatment of cancer – a medicinal chemistry update

3. New tubulin targeting agents currently in clinical development

4. How Do Microtubule-Targeted Drugs Work? An Overview

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