Chemical modification of the adeno-associated virus capsid to improve gene delivery-Reference-Cited by-同舟云学术

Chemical modification of the adeno-associated virus capsid to improve gene delivery

Published:2020 Issue:4 Volume:11 Page:1122-1131
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mével Mathieu¹²³⁴⁵^ORCID,Bouzelha Mohammed¹²³⁴⁵,Leray Aurélien¹²³⁴⁵,Pacouret Simon¹²³⁴⁵,Guilbaud Mickael¹²³⁴⁵,Penaud-Budloo Magalie¹²³⁴⁵,Alvarez-Dorta Dimitri⁶⁷⁸⁹¹⁰,Dubreil Laurence¹¹¹²¹³¹⁴⁵,Gouin Sébastien G.⁶⁷⁸⁹¹⁰^ORCID,Combal Jean Philippe¹⁵¹⁶⁵,Hommel Mirja¹⁷¹⁸¹⁹²⁰²¹,Gonzalez-Aseguinolaza Gloria¹⁵¹⁶⁵¹⁷¹⁸,Blouin Véronique¹²³⁴⁵,Moullier Philippe¹²³⁴⁵,Adjali Oumeya¹²³⁴⁵,Deniaud David⁶⁷⁸⁹¹⁰^ORCID,Ayuso Eduard¹²³⁴⁵

Affiliation:

1. INSERM UMR 1089

2. Université de Nantes

3. CHU de Nantes

4. 44200 Nantes

5. France

6. LUNAM Université

7. CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation

8. UMR CNRS 6230

9. UFR des Sciences et des Techniques

10. 44322 Nantes

11. PanTher-UMR 703

12. INRA-ONIRIS

13. Atlanpole-Chanterie

14. 44307 Nantes

15. Vivet Therapeutics SAS

16. Paris

17. Gene Therapy and Regulation of Gene Expression Program

18. CIMA

19. FIMA

20. University of Navarra

21. Navarra Institute for Health Research (IdisNA)

Abstract

Bioconjugated AAV vectors, achieved by coupling of ligands on amino groups of the capsid, are of great interest for gene delivery. Chemical modifications can be used to enhance cell tropism and to decrease interactions with neutralizing antibodies.

Funder

Institut National de la Santé et de la Recherche Médicale

Université de Nantes

Centre Hospitalier Universitaire de Nantes

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC04189C

Reference39 articles.