Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging

Author:

Gómez-González Elisabet1ORCID,Caro Carlos23ORCID,Núñez Nuria O.1ORCID,González-Mancebo Daniel1,Urbano-Gámez Jesús D.23,García-Martín Maria L.234ORCID,Ocaña Manuel1ORCID

Affiliation:

1. Instituto de Ciencia de Materiales de Sevilla (CSIC-US), c/Américo Vespucio, 49, 41092 Sevilla, Spain

2. Biomedical Magnetic Resonance Laboratory-BMRL, Andalusian Public Foundation Progress and Health-FPS, Seville, Spain

3. Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina–IBIMA Plataforma Bionand, C/Severo Ochoa, 35, 29590 Malaga, Spain

4. Biomedical Research Networking Center in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 28029 Madrid, Spain

Abstract

NaLn(WO4)2 (Ln = Dy or Ho) nanoparticles functionalized with polyacrylic acid exhibit excellent performance as bimodal contrast agents for high-field MRI and X-ray computed tomography bioimaging and show tumor targeting ability through the EPR effect.

Funder

Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

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