Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

Author:

Dong Wei1,Huang Yujie1,Shu Yifan1,Fan Xia1,Tian Xinyi1,Yan Yamei23,Mi Jia23,Lu Lu23,Zeng Xiaoxiong1ORCID,Cao Youlong23

Affiliation:

1. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China

2. Institute of Wolfberry Engineering Technology, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, 750002, Ningxia, China

3. National Wolfberry Engineering Research Center, Yinchuan 750002, Ningxia, China

Abstract

Water extract of Goji berries ameliorated neuroinflammation and cognitive impairment in HFFD-induced mice, which might be due to the regulation of bile acids (BAs) homeostasis and gut microbiota.

Funder

Key Research and Development Program of Ningxia

Nanjing Agricultural University

National Natural Science Foundation of China

Guizhou Science and Technology Department

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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