Investigations of the reactivity, stability and biological activity of halido (NHC)gold(i) complexes-Reference-Cited by-同舟云学术

Investigations of the reactivity, stability and biological activity of halido (NHC)gold(i) complexes

Published:2022 Issue:4 Volume:51 Page:1395-1406
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Goetzfried Sina Katharina¹^ORCID,Kapitza Paul¹,Gallati Caroline Marie¹,Nindl Anna²³,Cziferszky Monika¹^ORCID,Hermann Martin⁴,Wurst Klaus⁵,Kircher Brigitte²³,Gust Ronald¹^ORCID

Affiliation:

1. Institute of Pharmacy, Department of Pharmaceutical Chemistry, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria

2. Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria

3. Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria

4. Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria

5. Institute for General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria

Abstract

The significance of the halido ligand (Cl−, Br−, I−) in (NHC)gold(i) complexes in ligand exchange reactions, including the ligand scrambling to the bis(NHC)gold(i) complex 5, was evaluated by HPLC and discussed in relation to the biological activity in A2780 cell lines.

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03528B

Reference51 articles.

1. New insights in Au-NHCs complexes as anticancer agents

2. On the medicinal chemistry of gold complexes as anticancer drugs

3. A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

4. Recent advances in gold–NHC complexes with biological properties

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