A dual-function chromogenic and fluorogenic benzofurazan probe for plazomicin and its innovative utility for development of two microwell assays with high throughput for analysis of drug substance and pharmaceutical formulations

Author:

Alkathiri Fai A.1ORCID,Al-Outaibi Majed2,Darwish Ibrahim A.2ORCID

Affiliation:

1. Department of Pharmaceutics, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia

2. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia

Abstract

NBD-F was evaluated as a dual-function probe chromogenic and fluorogenic probe and employed in the development of microwell-based photometric and fluorometric assays for the quantitative determination of PLZ in its bulk drug and Zemedri® injections.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Reference30 articles.

1. Plazomicin: an intravenous aminoglycoside antibacterial for the treatment of complicated urinary tract infections

2. Plazomicin for the treatment of patients with complicated urinary tract infection

3. FDA, ZEMDRI™ Prescribing Information, available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210303orig1s000lbl.pdf , accessed on June 29, 2024

4. Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review

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