All-in-one HN@Cu-MOF nanoparticles with enhanced reactive oxygen species generation and GSH depletion for effective tumor treatment-Reference-Cited by-同舟云学术

All-in-one HN@Cu-MOF nanoparticles with enhanced reactive oxygen species generation and GSH depletion for effective tumor treatment

Published:2023 Issue:48 Volume:11 Page:11519-11531
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Chen Shuhui¹,Yan Yu¹,Chen Yixuan¹,Wang Kaili¹,Zhang Yawen¹,Wang Xinlong¹,Li Xurui¹,Wen Jian²^ORCID,Yuan Yue¹^ORCID

Affiliation:

1. School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China

2. Department of Breast Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshan East Road, Shenyang, Liaoning, 110032, P. R. China

Abstract

The multi-functional nanoparticle HN@Cu-MOF integrates PDT/CDT/GT, leading to a significant enhancement in GSH consumption and an elevation in ROS production, initiating the sensitization to PDT and cell apoptosis in the treatment of tumors.

Funder

Shenyang Key Laboratory of Functional Drug Carrier Materials

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D3TB02433D

Reference49 articles.

1. Functional Nanomaterials for Phototherapies of Cancer

2. Platinum(IV) complex-based two-in-one polyprodrug for a combinatorial chemo-photodynamic therapy

3. Nanocomposite-Based Photodynamic Therapy Strategies for Deep Tumor Treatment