Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia

Author:

Bentea Eduard12345ORCID,Depasquale Erica A. K.6789,O’Donovan Sinead M.1011129,Sullivan Courtney R.13149,Simmons Micah1516179,Meador-Woodruff James H.1516179,Zhou Ying1819209,Xu Chongchong1819209,Bai Bing212223249,Peng Junmin212223249,Song Hongjun252627928,Ming Guo-li252627928,Meller Jarek678929,Wen Zhexing1819209,McCullumsmith Robert E.1011129

Affiliation:

1. Center for Neurosciences (C4N)

2. Department of Pharmaceutical Biotechnology and Molecular Biology

3. Vrije Universiteit Brussel

4. Brussels

5. Belgium

6. Department of Biomedical Informatics

7. Cincinnati Children's Hospital Medical Center

8. Cincinnati

9. USA

10. Department of Neurosciences

11. University of Toledo College of Medicine

12. Toledo

13. Cyagen US

14. San Diego

15. Department of Psychiatry and Behavioral Neurobiology

16. University of Alabama at Birmingham

17. Birmingham

18. Departments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurology

19. Emory University School of Medicine

20. Atlanta

21. Departments of Structural Biology and Developmental Neurobiology

22. Center for Proteomics and Metabolomics

23. St. Jude Children's Research Hospital

24. Memphis

25. Department of Neuroscience and Mahoney Institute for Neurosciences

26. University of Pennsylvania

27. Philadelphia

28. Department of Cell and Developmental Biology

29. Departments of Environmental Health, Electrical Engineering & Computing Systems and Biomedical Informatics

Abstract

iPSCs from a schizophrenia patient harboring a mutation in the DISC1 gene show large scale abnormalities in serine/threonine kinase activity.

Funder

Alzheimer's Disease Research Center, Emory University

National Institute of Mental Health

National Institute of Allergy and Infectious Diseases

Edward Mallinckrodt, Jr. Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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