Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia-Reference-Cited by-同舟云学术

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Kinase network dysregulation in a human induced pluripotent stem cell model of DISC1 schizophrenia

Published:2019 Issue:3 Volume:15 Page:173-188
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Bentea Eduard¹²³⁴⁵^ORCID,Depasquale Erica A. K.⁶⁷⁸⁹,O’Donovan Sinead M.¹⁰¹¹¹²⁹,Sullivan Courtney R.¹³¹⁴⁹,Simmons Micah¹⁵¹⁶¹⁷⁹,Meador-Woodruff James H.¹⁵¹⁶¹⁷⁹,Zhou Ying¹⁸¹⁹²⁰⁹,Xu Chongchong¹⁸¹⁹²⁰⁹,Bai Bing²¹²²²³²⁴⁹,Peng Junmin²¹²²²³²⁴⁹,Song Hongjun²⁵²⁶²⁷⁹²⁸,Ming Guo-li²⁵²⁶²⁷⁹²⁸,Meller Jarek⁶⁷⁸⁹²⁹,Wen Zhexing¹⁸¹⁹²⁰⁹,McCullumsmith Robert E.¹⁰¹¹¹²⁹

Affiliation:

1. Center for Neurosciences (C4N)

2. Department of Pharmaceutical Biotechnology and Molecular Biology

3. Vrije Universiteit Brussel

4. Brussels

5. Belgium

6. Department of Biomedical Informatics

7. Cincinnati Children's Hospital Medical Center

8. Cincinnati

9. USA

10. Department of Neurosciences

11. University of Toledo College of Medicine

12. Toledo

13. Cyagen US

14. San Diego

15. Department of Psychiatry and Behavioral Neurobiology

16. University of Alabama at Birmingham

17. Birmingham

18. Departments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurology

19. Emory University School of Medicine

20. Atlanta

21. Departments of Structural Biology and Developmental Neurobiology

22. Center for Proteomics and Metabolomics

23. St. Jude Children's Research Hospital

24. Memphis

25. Department of Neuroscience and Mahoney Institute for Neurosciences

26. University of Pennsylvania

27. Philadelphia

28. Department of Cell and Developmental Biology

29. Departments of Environmental Health, Electrical Engineering & Computing Systems and Biomedical Informatics

Abstract

iPSCs from a schizophrenia patient harboring a mutation in the DISC1 gene show large scale abnormalities in serine/threonine kinase activity.

Funder

Alzheimer's Disease Research Center, Emory University

National Institute of Mental Health

National Institute of Allergy and Infectious Diseases

Edward Mallinckrodt, Jr. Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MO/C8MO00173A

Reference61 articles.

1. Schizophrenia

2. The Global Prevalence of Schizophrenia

3. Twin studies of schizophrenia: From bow-and-arrow concordances to Star Wars Mx and functional genomics

4. Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

5. A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder

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