A near-infrared fluorescent probe based on a hemi-cyanine skeleton for detecting CES1 activity and evaluating pesticide toxicity

Author:

Zhao Xin1,Tian Manman2,Wang Yan23,Yang Fangyu4,Liang Guobiao4,Tian Xiangge2ORCID,Feng Lei2ORCID,Cui Jingnan1ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

2. Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, 116023, China

3. College of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, China

4. General Hospital of Northern Theater Command, Department of Neurosurgery, Shenyang, China

Abstract

A novel near-infrared (NIR) fluorescent probe CHC-CES1 based on a hemi-cyanine skeleton for detecting carboxylesterase 1 (CES1) activity was developed and applied for the evaluation of pesticide toxicity.

Funder

Traditional Chinese Medicine Bureau of Guangdong Province

Science, Technology and Innovation Commission of Shenzhen Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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