2,3-Disubstituted-1,4-naphthoquinones containing an arylamine with trifluoromethyl group: synthesis, biological evaluation, and computational study

Author:

Yıldırım Hatice12345ORCID,Bayrak Nilüfer12345ORCID,Tuyun Amac Fatih62345ORCID,Kara Emel Mataracı78345,Çelik Berna Özbek78345,Gupta Girish Kumar910111213ORCID

Affiliation:

1. Chemistry Department

2. Engineering Faculty

3. Istanbul University

4. Istanbul

5. Turkey

6. Engineering Sciences Department

7. Pharmaceutical Microbiology Department

8. Pharmacy Faculty

9. Department of Pharmaceutical Chemistry

10. Maharishi Markandeshwar College of Pharmacy

11. Maharishi Markandeshwar University

12. Ambala 133207

13. India

Abstract

Antimicrobial and antibiofilm activities were evaluated. Two compounds (5b and 5e) were identified as the hits against S. epidermidis. Compounds 5b and 5e showed promising antibacterial and antibiofilm activities.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference51 articles.

1. Changing patterns of infectious disease

2. Infectious Diseases: Considerations for the 21st Century

3. World Health Organization , Mortality and Global Health Estimates, Geneva, Switzerland, 2013

4. Global rise in human infectious disease outbreaks

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