Enantioselective construction of 3-substituted 3-amino-2-oxindoles containing an N,N-ketal skeleton via organocatalyzed aza-addition of isatin imines-Reference-Cited by-同舟云学术

Enantioselective construction of 3-substituted 3-amino-2-oxindoles containing an N,N-ketal skeleton via organocatalyzed aza-addition of isatin imines

Published:2019 Issue:36 Volume:17 Page:8374-8378
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Chen¹²³⁴⁵,Shang Xinye¹²³⁴⁵,Cheng Yuyu⁶⁷⁸⁵,Li Fushuai¹²³⁴⁵,Zhao Hanhui¹²³⁴⁵,Li Pengfei⁶⁷⁸⁵^ORCID,Li Wenjun¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Qingdao University

4. Qingdao 266021

5. China

6. Department of Chemistry and Shenzhen Key Laboratory of Marine Archaea Geo-Omics

7. Southern University of Science and Technology

8. Shenzhen 518055

Abstract

The first example of organocatalytic chemo-, regio- and enantioselective aza-Mannich reactions of triazoles and arylamines, respectively, with isatin-derived imines has been achieved.

Funder

National Natural Science Foundation of China

Taishan Scholar Project of Shandong Province

Natural Science Foundation of Shandong Province

Shenzhen Science and Technology Innovation Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01870K

Reference39 articles.

1. Synthesis of novel spiro[pyrazolo[4,3- d ]pyrimidinones and spiro[benzo[4,5]thieno[2,3- d ]pyrimidine-2,3′-indoline]-2′,4(3H)-diones and their evaluation for anticancer activity

2. Synthesis of novel 7-aryl and 7-spiropyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors

3. Indole Alkaloids from Cephalanceropsis gracilis

4. Synthesis and structure elucidation of novel fused 1,2,4-triazine derivatives as potent inhibitors targeting CYP1A1 activity

5. Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines

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