A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution-Reference-Cited by-同舟云学术

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Published:2019 Issue:40 Volume:17 Page:8982-8986
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lauder Kate¹²³⁴^ORCID,Masci Domiziana¹²³⁴,Toscani Anita¹²³⁴,Al Mekdad Aya¹²³⁴,Black Gary W.⁵⁶⁷⁴^ORCID,Brown Nicola L.⁵⁶⁷⁴,Turner Nicholas J.⁸⁹¹⁰¹¹⁴^ORCID,Luisi Renzo¹²¹³¹⁴¹⁵^ORCID,Castagnolo Daniele¹²³⁴^ORCID

Affiliation:

1. School of Cancer and Pharmaceutical Sciences

2. King's College London

3. London

4. UK

5. Department of Applied Sciences

6. Northumbria University

7. Newcastle upon Tyne

8. School of Chemistry

9. Manchester Institute of Biotechnology

10. University of Manchester

11. Manchester

12. Department of Pharmacy - Drug Sciences

13. University of Bari“A. Moro”

14. Bari 70125

15. Italy

Abstract

A microwave assisted multicomponent protocol on water allows the regioselective synthesis of chiral aryl-1,2-mercaptoamines. The enzymatic resolution of the racemates leads to enantioenriched products.

Funder

Royal Society

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

University of London

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01962F

Reference51 articles.