Tetrazine-mediated bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of nitric oxide in vivo-Reference-Cited by-同舟云学术

Tetrazine-mediated bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of nitric oxide in vivo

Published:2021 Issue:5 Volume:9 Page:1816-1825
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wu Jianbing¹²³⁴⁵^ORCID,Sun Tao¹²³⁴⁵^ORCID,Yang Chenxi⁶⁷⁸⁹⁵,Lv Tian⁶⁷⁸⁹⁵,Bi Yuyang⁶⁷⁸⁹⁵,Xu Yuan⁶⁷⁸⁹⁵,Ling Yong¹⁰¹¹¹²⁵^ORCID,Zhao Jun¹²³⁴⁵^ORCID,Cong Rigang¹³¹⁴¹⁵¹⁶⁵,Zhang Yihua⁶⁷⁸⁹⁵,Wang Jianhua¹²³⁴⁵,Wen Hao¹²³⁴⁵,Jiang Hulin¹²³⁴⁵^ORCID,Li Fei⁶⁷⁸⁹⁵,Huang Zhangjian¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Pathogenesis

2. Prevention and Treatment of High Incidence Diseases in Central Asia

3. Xinjiang Medical University

4. Urumqi

5. P.R. China

6. State Key Laboratory of Natural Medicines

7. Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases

8. China Pharmaceutical University

9. Nanjing 210009

10. School of Pharmacy

11. Nantong University

12. Nantong

13. National-certified Enterprise Technology Center

14. Disha Pharmaceutical Group Co.

15. Ltd.

16. Weihai 264205

Abstract

3a can be triggered by BTZ and then liberate NO and acrolein. By liposomes of 3a and BTZ, the bioorthogonal reactions between them was limited within the implanted cancer cells in zebrafish, thus generating potent cancer inhibitory activity.

Funder

National Natural Science Foundation of China

National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology

State Key Laboratory of Natural Medicines

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01841D

Reference47 articles.

1. Cell Surface Engineering by a Modified Staudinger Reaction