Genome mining for fungal polyketide-diterpenoid hybrids: discovery of key terpene cyclases and multifunctional P450s for structural diversification-Reference-Cited by-同舟云学术

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Genome mining for fungal polyketide-diterpenoid hybrids: discovery of key terpene cyclases and multifunctional P450s for structural diversification

Published:2019 Issue:5 Volume:6 Page:571-578
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wang Wei-Guang¹²³⁴⁵^ORCID,Du Lian-Qiong¹²³⁴⁵,Sheng Shan-Ling¹²³⁴⁵,Li Ao⁶⁷⁸⁹,Li Yan-Ping¹⁰¹¹¹²⁵,Cheng Gui-Guang¹³¹⁴¹⁵⁵,Li Gan-Peng¹²³⁴⁵,Sun Guiling¹⁶¹⁷¹⁸¹⁹²⁰,Hu Qiu-Fen¹²³⁴⁵,Matsuda Yudai²¹²²²³⁵^ORCID

Affiliation:

1. Key Laboratory of Chemistry in Ethnic Medicinal Resources

2. State Ethnic Affairs Commission and Ministry of Education

3. Yunnan Minzu University

4. Kunming 650031

5. China

6. College of Pharmacy and Bioengineering

7. Chongqing University of Technology

8. Chongqing 400054

9. People's Republic of China

10. School of Chinese Pharmacy

11. Yunnan University of Traditional Chinese Medicine

12. Kunming 650500

13. Yunnan Institute of Food Safety

14. Kunming University of Science and Technology

15. Kunming

16. Key Laboratory of Plant Stress Biology

17. State Key Laboratory of Cotton Biology

18. School of Life Sciences

19. Henan University

20. Kaifeng 475004

21. Department of Chemistry

22. City University of Hong Kong

23. Kowloon

Abstract

The biosynthesis of the fungal meroterpenoid chevalone E and its derivatives has been successfully elucidated and reconstituted.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Yunnan Province

Yunnan Provincial Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C8QO01124A

Reference39 articles.

1. Meroterpenoids produced by fungi

2. Biosynthesis of fungal meroterpenoids

3. Total synthesis of complex terpenoids employing radical cascade processes

4. Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens

5. New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145

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4. Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle;International Journal of Molecular Sciences;2023-07-06

5. Dissection of the Catalytic Mechanisms of Transmembrane Terpene Cyclases Involved in Fungal Meroterpenoid Biosynthesis;Angewandte Chemie International Edition;2023-06-16

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