Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel-Reference-Cited by-同舟云学术

Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel

Published:2015 Issue:19 Volume:5 Page:14482-14491
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lee DaeYong¹²³⁴,Choe Kibaek⁵²³⁴,Jeong YongJun¹²³⁴,Yoo Jisang¹²³⁴,Lee Sung Mun⁶⁷⁸⁹,Park Ji-Ho¹⁰²³⁴,Kim Pilhan⁵²³⁴,Kim Yeu-Chun¹²³⁴

Affiliation:

1. Department of Chemical and Biomolecular Engineering

2. Korea Advanced Institute of Science and Technology (KAIST)

3. Daejeon 305-701

4. Republic of Korea

5. Graduate school of Nanoscience and Technology

6. Department of Biomedical Engineering

7. Khalifa University of Science, Technology and Research (KUSTAR)

8. Abu Dhabi 127-788

9. UAE

10. Department of Bio and Brain Engineering

Abstract

Glucose-responsive glycol chitosan/sodium alginate-poly(l-glutmate-co-N-3-l-glutamylphenylboronic acid) double-layered nanogel is a promising platform for controlled insulin release systems, achieving glucose-triggered insulin release at diabetic glucose levels in vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA16656F

Reference30 articles.

1. Polymeric hydrogels for oral insulin delivery

2. Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH

3. Microneedles for drug and vaccine delivery

4. Facile one-pot synthesis of glucose-sensitive nanogel via thiol-ene click chemistry for self-regulated drug delivery

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