Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent-Reference-Cited by-同舟云学术

Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent

Published:2020 Issue:68 Volume:56 Page:9795-9798
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hwang Soo-Yeon¹²³⁴,Park Soo-Yeon⁵⁶⁷⁸³,Hong Jung Yeon⁹¹⁰¹¹⁸³,Lee Soo Yeon⁵⁶⁷⁸³,Shin Jae-Ho¹²¹³¹⁴⁴,Na Younghwa¹²¹³¹⁴⁴,Sohn Myung Hyun⁹¹⁰¹¹⁸³,Yoon Ho-Geun⁵⁶⁷⁸³,Kwon Youngjoo¹²³⁴^ORCID

Affiliation:

1. College of Pharmacy & Graduate School of Pharmaceutical Sciences

2. Ewha Womans University

3. Seoul

4. Korea

5. Department of Biochemistry and Molecular Biology

6. Severance Medical Research Institute

7. Brain Korea 21 PLUS Project for Medical Sciences

8. Yonsei University College of Medicine

9. Department of Pediatrics

10. Institute of Allergy

11. Brain Korea 21 PLUS Project for Medical Science

12. College of Pharmacy

13. CHA University

14. Pocheon

Abstract

Using a field-based design approach, we systematically identified a novel potent p300 inhibitor, A6, with effective anti-fibrotic activity and favorable drug-like properties.

Funder

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC03553J

Reference23 articles.

1. Cellular and molecular mechanisms of fibrosis

2. Mechanisms of fibrosis: therapeutic translation for fibrotic disease

3. Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis

4. Reversal of Fibrosis: No Longer a Pipe Dream?

5. The rising incidence of idiopathic pulmonary fibrosis in the UK

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