Synthesis of novel and potent vorapaxar analogues
Author:
Affiliation:
1. Department of Chemistry
2. University College London
3. London
4. UK
5. Centre for Inflammation and Tissue Repair
6. London WC1E 6JJ
7. GSK
8. Stevenage
Abstract
Unlocking novel and potent vorapaxar analogues by functionalisation of previously unexplored positions on the parent vorapaxar scaffold.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02541A
Reference16 articles.
1. Secondary Prevention of Cardiovascular Disease With Vorapaxar
2. Coagulation and coagulation signalling in fibrosis
3. A New Strategy for the Synthesis of Himbacine
4. a highly stereoselective synthesis of carbocyclic compounds by the michael induced intramolecular alkylation a stereocontrol of extracyclic chiral centers
5. Total Syntheses of (−)-Grandinolide and (−)-Sapranthin by the Sharpless Asymmetric Dihydroxylation of Methyltrans-3-Pentenoate: Elucidation of the Stereostructure of (−)-Sapranthin
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