<i>C</i>-Methylation controls the biosynthetic programming of alternapyrone-Reference-Cited by-同舟云学术

C-Methylation controls the biosynthetic programming of alternapyrone

Published:2022 Issue:25 Volume:20 Page:5050-5054
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Phakeovilay Jaiyfungkhong¹,Imaram Witcha²,Vuttipongchaikij Supachai³,Bunnak Waraporn²,Lazarus Colin M.⁴,Wattana-Amorn Pakorn¹²^ORCID

Affiliation:

1. Interdisciplinary Program in Genetic Engineering and Bioinformatics, Graduate School, Kasetsart University, Bangkok, 10900, Thailand

2. Department of Chemistry, Special Research Unit for Advanced Magnetic Resonance and Center of Excellence for Innovation in Chemistry, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand

3. Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand

4. School of Biological Sciences, University of Bristol, Bristol, BS8 1TQ, UK

Abstract

Mutations of the C-methyltransferase (C-MeT) domain of alternapyrone polyketide synthase (AltPKS) resulted in no production of any non-methylated polyketides indicating the importance of C-methylation for biosynthetic programming of alternapyrone.

Funder

Kasetsart University Research and Development Institute

Center of Excellence for Innovation in Chemistry

Ministry of Higher Education, Science, Research and Innovation, Thailand

Graduate School, Kasetsart University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00947A

Reference22 articles.