Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood

Author:

Pandey Sangeeta1,Hu Yanyang1,Anderson Peter L.2,Kiser Jennifer J.2,Cooks R. Graham1ORCID

Affiliation:

1. Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA

Abstract

We demonstrate proof-of-concept for point-of-care assessment of long-term alcohol consumption by measuring phosphatidylethanol in blood/dried blood spots with nano-electrospray ionization and MS/MS using a miniature mass spectrometer.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference36 articles.

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2. Centers for Disease Control and Prevention , Excessive Alcohol Use, https://www.cdc.gov/chronicdisease/resources/publications/factsheets/alcohol.html

3. WHO , Alcohol, https://www.who.int/news-room/fact-sheets/detail/alcohol

4. NIAAA , Alcohol's Effects on the Body | National Institute on Alcohol Abuse and Alcoholism (NIAAA), https://www.niaaa.nih.gov/alcohols-effects-health/alcohols-effects-body

5. National Institute on Alcohol and Alcoholism, Alcohol Facts and Statistics | National Institute on Alcohol Abuse and Alcoholism (NIAAA), https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/alcohol-facts-and-statistics

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