Spontaneous conversion of prenyl halides to acids: application in metal-free preparation of deuterated compounds under mild conditions-Reference-Cited by-同舟云学术

Spontaneous conversion of prenyl halides to acids: application in metal-free preparation of deuterated compounds under mild conditions

Published:2021 Issue:34 Volume:19 Page:7390-7402
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Darshana Dhanushka¹^ORCID,Sureram Sanya²,Mahidol Chulabhorn¹²^ORCID,Ruchirawat Somsak¹²³^ORCID,Kittakoop Prasat¹²³^ORCID

Affiliation:

1. Chulabhorn Graduate Institute, Chemical Biology Program, Chulabhorn Royal Academy, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand

2. Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand

3. Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand

Abstract

Unprecedented spontaneous conversion of prenyl halides to acid (DX) was observed in CD3OD. In situ generation of DX was applied for metal-free preparation of a broad range of deuterated compounds, with no chromatographic separation.

Funder

National Research Council of Thailand

Thailand Science Research and Innovation

Science and Technology Postgraduate Education and Research Development Office, Office of the Higher Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01275D

Reference64 articles.

1. The Renaissance of H/D Exchange

2. C−H Functionalisation for Hydrogen Isotope Exchange

3. Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences

4. Electrolytic deuteration of unsaturated bonds without using D2

5. Iridium-Catalyzed Formyl-Selective Deuteration of Aldehydes

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