Physical stability enhancement and antimicrobial properties of a sodium ionic cocrystal with theophylline

Author:

Majodina Siphumelele1234,Ndima Lubabalo1234,Abosede Olufunso O.1234,Hosten Eric C.1234ORCID,Lorentino Carolline M. A.56789ORCID,Frota Heloísa F.56789,Sangenito Leandro S.56789,Branquinha Marta H.56789,Santos André L. S.56789,Ogunlaja Adeniyi S.1234ORCID

Affiliation:

1. Department of Chemistry

2. Nelson Mandela University

3. Port Elizabeth 6031

4. South Africa

5. Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes

6. Departamento de Microbiologia Geral

7. Instituto de Microbiologia Paulo de Góes

8. Universidade Federal do Rio de Janeiro

9. Rio de Janeiro

Abstract

In the present study, we have described the synthesis and characterisation of the theophylline hydrate (Theo hydrate), cocrystal (Theo–Phen·2H2O) and hydrated sodium co-crystal of theophylline (Na–(Theo)2ClO·2H2O), where Theo = theophylline and Phen = 1,10-phenathroline.

Funder

National Research Foundation

Nelson Mandela University

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

International Union of Pure and Applied Chemistry

United Nations Educational, Scientific and Cultural Organization

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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