Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

Published:2019 Issue:50 Volume:9 Page:29273-29292
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Srinivasarao Singireddi¹²³⁴,Nandikolla Adinarayana¹²³⁴,Nizalapur Shashidhar⁵⁶⁷,Yu Tsz Tin⁵⁶⁷,Pulya Sravani⁸²⁹⁴,Ghosh Balaram⁸²⁹⁴,Murugesan Sankaranarayanan¹⁰⁸²¹¹⁴,Kumar Naresh⁵⁶⁷^ORCID,Chandra Sekhar Kondapalli Venkata Gowri¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Birla Institute of Technology and Science

3. Hyderabad – 500078

4. India

5. School of Chemistry

6. UNSW Sydney

7. Australia

8. Department of Pharmacy

9. Hyderabad-500078

10. Medicinal Chemistry Research Laboratory

11. Pilani

Abstract

Out of 40 benzimdazoles, 12 exhibited potent QSI activity against P. aeruginosa6p, most active QSI is docked to LasR and is less toxic against HEK 293 cell line.

Funder

Department of Biotechnology, Ministry of Science and Technology

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA05059K

Reference41 articles.

1. Cellâcell signalling in bacteria: not simply a matter of quorum

2. Modulation of Bacterial Quorum Sensing with Synthetic Ligands: Systematic Evaluation of N-Acylated Homoserine Lactones in Multiple Species and New Insights into Their Mechanisms of Action