A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1-Reference-Cited by-同舟云学术

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A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1

Published:2016 Issue:5 Volume:7 Page:999-1002
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Foley David W.¹²³⁴⁵,Bermudez Isabel⁶⁷⁸⁹⁴,Bailey Patrick D.⁵¹⁰¹¹¹²⁴,Meredith David⁶⁷⁸⁹⁴

Affiliation:

1. School of Chemistry

2. University of Manchester

3. Manchester

4. UK

5. EPSAM Research Institute

6. Department of Biological & Medical Sciences

7. Faculty of Health & Life Sciences

8. Oxford Brookes University

9. Oxford OX3 0BP

10. Faculty of Natural Sciences

11. Keele University

12. Staffordshire

Abstract

Cyclosporine was attached to a thiodipeptide carrier, yielding conjugate 7; this is a substrate for PepT1 with oral bioavailability potential.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00575B

Reference19 articles.

1. The Future of Peptide-based Drugs

2. Challenges for the oral delivery of macromolecules

3. Oral Delivery of Peptide Drugs

4. Is the oral route possible for peptide and protein drug delivery?

5. Drug transport via the intestinal peptide transporter PepT1

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chitosan Membranes Filled with Cyclosporine A as Possible Devices for Local Administration of Drugs in the Treatment of Breast Cancer;Molecules;2021-03-26

2. PTR2/POT/NPF transporters: what makes them tick?;Advances in Protein Chemistry and Structural Biology;2021

3. Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery;European Journal of Medicinal Chemistry;2018-08

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