Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases-Reference-Cited by-同舟云学术

Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases

Published:2016 Issue:4 Volume:7 Page:2821-2826
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Reuillon Tristan¹²³⁴⁵,Alhasan Sari F.¹²³⁴⁵,Beale Gary S.¹²³⁴⁵,Bertoli Annalisa¹²³⁴⁵,Brennan Alfie¹²³⁴⁵,Cano Celine¹²³⁴⁵,Reeves Helen L.¹²³⁴⁵,Newell David R.¹²³⁴⁵,Golding Bernard T.¹²³⁴⁵,Miller Duncan C.¹²³⁴⁵,Griffin Roger J.¹²³⁴⁵

Affiliation:

1. Newcastle Cancer Centre

2. Northern Institute for Cancer Research

3. School of Chemistry

4. Newcastle University

5. Newcastle Upon Tyne

Abstract

Two series of inhibitors of sulfatase 2, ARSA and ARSB were designed based on biphenyl and biphenyl ether scaffolds substituted with e.g. sulfamate and carboxylate groups.

Funder

Cancer Research UK

Pfizer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03612G

Reference21 articles.

1. Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans

2. HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1