Discovery of C-shaped aurone human neutrophil elastase inhibitors-Reference-Cited by-同舟云学术

Discovery of C-shaped aurone human neutrophil elastase inhibitors

Published:2015 Issue:8 Volume:6 Page:1508-1512
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Lucas S. D.¹²³⁴⁵,Carrasco M. P.¹²³⁴⁵,Gonçalves L. M.¹²³⁴⁵,Moreira R.¹²³⁴⁵,Guedes R. C.¹²³⁴⁵

Affiliation:

1. Research Institute for Medicines (iMed.ULisboa)

2. Faculty of Pharmacy

3. Universidade de Lisboa

4. 1649-003 Lisboa

5. Portugal

Abstract

Aurones were discovered as sub-micromolar HNE inhibitors. The activity is rationalized by a C-shape conformation that allows tight binding to HNE S1 and S2 pockets.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00164A

Reference22 articles.

1. Targeting COPD: advances on low-molecular-weight inhibitors of human neutrophil elastase

2. Neutrophil Elastase as a Target in Lung Cancer

3. Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations

4. Unexpected Active-Site Flexibility in the Structure of Human Neutrophil Elastase in Complex with a New Dihydropyrimidone Inhibitor

5. F. von Nussbaum , V.Li , S.Anlauf , M.Bechem , M.Delbeck , H.Gielen-Haertwig , A.Harrenga , H.Haning , D.Karthaus , D.Lang , K.Lustig , D.Meibom , J.Mittendorf , M.Schäfer , S.Schäfer and J.Schamberger , presented in part at the XXIII International Symposium on Medicinal Chemistry, Lisbon, Portugal , 2014

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Human neutrophil elastase inhibitors: Classification, biological‐synthetic sources and their relevance in related diseases;Fundamental & Clinical Pharmacology;2023-08-23

2. Recent advances in the development of elastase inhibitors;Future Medicinal Chemistry;2020-10

3. Electrosynthesis of a Biaurone by Controlled Dimerization of Flavone: Mechanistic Insight and Large-Scale Application;The Journal of Organic Chemistry;2020-07-20

4. Aurone: A biologically attractive scaffold as anticancer agent;European Journal of Medicinal Chemistry;2019-03

5. Limitation of Algar–Flynn–Oyamada reaction using methoxy substituted chalcones as reactants and evaluation of the newly transformed aurones for their biological activities;Research on Chemical Intermediates;2016-11-03