Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies-Reference-Cited by-同舟云学术

Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies

Published:2016 Issue:3 Volume:18 Page:2034-2046
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Kong Xiaotian¹²³⁴⁵,Sun Huiyong⁵⁶⁷⁴,Pan Peichen⁵⁶⁷⁴,Tian Sheng¹²³⁴,Li Dan⁵⁶⁷⁴,Li Youyong¹²³⁴,Hou Tingjun¹²³⁴⁵

Affiliation:

1. Institute of Functional Nano and Soft Materials (FUNSOM)

2. Soochow University

3. Suzhou

4. P. R. China

5. College of Pharmaceutical Sciences

6. Zhejiang University

7. Hangzhou

Abstract

Due to the high sequence identity of the binding pockets of cyclin-dependent kinases (CDKs), designing highly selective inhibitors towards a specific CDK member remains a big challenge.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP05622E

Reference70 articles.

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4. Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

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