Diversified synthesis and α-selective glycosylation of 3-amino-2,3,6-trideoxy sugars

Author:

Zeng Jing1234ORCID,Wang Ruobin1234,Yao Wang1234,Zhang Shuxin1234,Sun Guangfei1234,Liao Zhiwen1234,Meng Lingkui1234,Wan Qian12345ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation

2. School of Pharmacy; Huazhong University of Science and Technology

3. Wuhan

4. China

5. Institute of Brain Research

Abstract

Quick access to various unnatural 3-amino-2,3,6-trideoxy sugars was achieved by sequential functionalization of a glycal intermediate. This strategy and the further glycosylation method allowed the efficient late-stage modification of bioactive natural products and drugs.

Funder

National Natural Science Foundation of China

State Key Laboratory of Bio-organic and Natural Products Chemistry

Huazhong University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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