Stretching the chains: the destabilizing impact of Cu<sup>2+</sup> and Zn<sup>2+</sup> ions on K48-linked diubiquitin-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Stretching the chains: the destabilizing impact of Cu²⁺ and Zn²⁺ ions on K48-linked diubiquitin

Published:2023 Issue:34 Volume:52 Page:11835-11849
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Mangini Vincenzo¹^ORCID,Grasso Giulia²,Belviso Benny Danilo¹^ORCID,Sciacca Michele F. M.²^ORCID,Lanza Valeria²^ORCID,Caliandro Rocco¹^ORCID,Milardi Danilo²^ORCID

Affiliation:

1. Istituto di Cristallografia - CNR sede di Bari, Via G. Amendola 122/O, 70126 Bari, Italy

2. Istituto di Cristallografia - CNR sede secondaria di Catania, Via P. Gaifami 18, 95126 Catania, Italy

Abstract

Cu2+ and Zn2+ ions play distinct roles in destabilizing the K48-Ub2 structure, causing separation of the ubiquitin monomers and highlighting their potential to interfere with Ub signalling.

Funder

Diamond Light Source

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT01815F

Reference66 articles.

1. Aggregates in neurodegenerative disease: crowds and power?

2. Role of K63-linked ubiquitination in cancer

3. The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges

4. THE UBIQUITIN SYSTEM

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP