Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity
Author:
Affiliation:
1. Dipartimento di Scienze e Innovazione Tecnologica
2. Università del Piemonte Orientale
3. 15121 Alessandria
4. Italy
5. Dipartimento di Biologia e Biotecnologie “L. Spallanzani”
6. Università di Pavia
7. 27100 Pavia
Abstract
The insertion of perillic acid in cisplatin-based antitumor Pt(iv) prodrugs confers them antimetastatic properties.
Funder
Università degli Studi del Piemonte Orientale
Ministero dell'Istruzione, dell'Università e della Ricerca
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT04051G
Reference100 articles.
1. Linking the future of anticancer metal-complexes to the therapy of tumour metastases
2. The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions
3. Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development
4. Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects
5. New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry
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